For patients who live with chronic migraine — 15 or more headache days per month — therapeutic Botox is one of the most effective preventative treatments available. At Alpha Medical Cyprus, we administer Botox for chronic migraine using the internationally validated PREEMPT protocol.
This article explains what migraine Botox is, who it is for, and why it is different from the cosmetic Botox most people know.
Chronic Migraine vs Episodic Migraine
Therapeutic Botox is specifically indicated for chronic migraine — meaning 15 or more headache days per month, with at least 8 of them migrainous, for at least 3 months. Patients with fewer days (episodic migraine) are usually better managed with acute and preventative medications first.
The PREEMPT Protocol
The PREEMPT protocol is the globally validated standard for migraine Botox. It uses 155-195 units of botulinum toxin across 31-39 precise injection points covering the forehead, temples, back of the head, neck and shoulders. The full treatment takes 15-20 minutes and is repeated every 12 weeks.
Why It Works
Botulinum toxin modulates the release of pain-related neurotransmitters and calms the muscular and neural triggers that contribute to migraine generation. Clinical studies consistently show significant reduction in migraine days and intensity across 2-3 treatment cycles.
Ready to take the next step? Book a consultation at our contact page — or request an introductory Migraine Treatment guide below.


